Andrew Luck takes on Tom Brady for the first time in the latest Colts-Patriots showdown.
A betting preview of every game (against the spread) on Sunday and Monday in Week 11.
Locks of the Week
Some fans in Kansas City plan on wearing funeral black to Arrowhead on Sunday, while Detroit fans may be close to breaking out their brown paper bags from the early 2000s.
Bengals (-3.5) at Chiefs
âThe fans are frustrated,â said Chiefs quarterback Matt Cassel. âHopefullyâ¦ we can change the atmosphere and environment around here.â Not this week.
Packers (-4) at Lions
Green Bay is fresh off its bye week and Aaron Rodgers carries a 7â1 record against Detroit, with five of those wins by five or more points.
The Keystone Stateâs quarterbacks â Ben Roethlisberger and Michael Vick â are banged up, making teams from the Beltway a better bet this weekend.
Ravens (-3.5) at Steelers
Byron Leftwich will start in place of Big Ben (right shoulder). Baltimore will look to make it three straight in Pittsburgh, after a pair of three-point wins in 2010 and â11.
Redskins (-4) vs. Eagles
Rookie Nick Foles makes his first career start in place of Vick (concussion). Skins coach Mike Shanahan puts his 10â6 record after a bye on the line.
Big numbers were a big letdown last week, but these three high-powered home teams should be able to take care of business against traditional losers this week.
Cowboys (-8) vs. Browns
If Big D canât put the smack down on Cleveland, heads will roll. Expect to see Jerry Jones on the sidelines celebrating late in this blowout win.
Falcons (-10) vs. Cardinals
Atlantaâs Matt Ryan has an 8â0 record in games immediately after a loss over the last two years and a 14â3 career mark after being defeated.
Texans (-15.5) vs. Jaguars
Houston beat J-Ville 27â7 in Week 2. Five of the Jagsâ eight losses have been by 16 or more points, with a pair of 17-point losses to the Lions and Colts the past two weeks.
These may not be straight up upsets, but keeping it close is not out of the question.
Raiders (+6) vs. Saints
New Orleans needs to march to victory, no doubt. But the West Coast bias at the Black Hole might not lend itself to a Big Easy blowout.
Chargers (+8) at Broncos
The Bolts were blitzed 35â24 by the Broncs in Week 6. But that week, Philip Rivers threw four INTs and coughed up two fumbles.
Steer clear of these bad boys, unless youâre a degenerate or a hometown homer who has to have action.
Buccaneers (-2) at Panthers
Cam Newton may have lost every press conference and all but two games this year, but this smells like a divisional upset for the Cats.
Rams (-3.5) vs. Jets
Jeff Fisher will play for the tie, unless you consider near-60-yard FG attempts as playing for the win. But itâs hard to push on a 3.5-point line.
Patriots (-9) vs. Colts
New England failed to cover against lowly Buffalo last week. But the stats show that Indy either wins or gets blown out â with three losses of 24, 20 and five points.
Off the Board
The big board in Vegas has a headache with the Monday night party between San Fran and Chi-town.
49ers (n/a) vs. Bears
Both Alex Smith and Jay Cutler suffered concussions last week. Letâs wager on what the line will be â take the Niners (-2.5) to cover.