What a truly wild weekend in the NFL it was as the road teams came in like conquering heroes across the country to capture several huge wins. While a repeat performance seems unlikely, it does reaffirm that outside of the top two or three teams, that the middle of the pack is just as jumbled as ever. That creates plenty of opportunity heading into Week 5 as lines have shifted and for sharp bettors to take advantage as a result.
Note: All times are ET and all games are on Sunday, Oct. 6.
Here are this week's best NFL picks against the spread:
Atlanta (1-3) at Houston (2-2), 1 p.m.
The Texans harbor hopes of winning the AFC South but were upended at home last week by Kyle Allen and the Panthers in a lackluster loss. Expect Bill O'Brien's squad to come out with a vengeance as they try to beat up on an Atlanta side that hasn't played well away from home at all and are dealing with a huge number of defensive issues. Houston’s offense should be able to move the ball efficiently so go ahead and lay those points. The Pick: Houston -4.5
New England (4-0) at Washington (0-4), 1 p.m.
The Pats have already blown out lower-rung teams like the Dolphins and Jets and Washington isn't any better than those two at the moment. Tom Brady and his offense were not super crisp on their trip to Buffalo last week but should have a much easier time against a secondary that continues to give up the big play. With Bill Belichick likely taking the best defense in the NFL to face off against a rookie quarterback, this one could get ugly in a hurry for the visitors. The Pick: New England -13
Denver (0-4) at Los Angeles Chargers (2-2), 4:05 p.m
Vic Fangio has come close but still hasn't gotten his cigar for a Broncos win just yet and at some point, all those close losses just keep piling up. The once-vaunted pass rush hasn't been great and while they might find some success against a questionable offensive line, Philip Rivers simply has too many weapons to drop a key division game. The Pick: Los Angeles -6.5
Indianapolis (2-2) at Kansas City (4-0), 8:20 p.m.
The Colts are simply beat up right now and missing a ton of key players, as RB Marlon Mack is questionable and WR T.Y. Hilton looks likely to miss a second game. The defense may wind up getting back Darius Leonard but still look quite thin — not something you want to hear when you're talking about facing off against Patrick Mahomes and company. The Chiefs return to Arrowhead for just the second time this year in what should be an electric atmosphere. KC rolls on Sunday night. The Pick: Kansas City -8.5
Last Week: 1-3
— Written by Bryan Fischer, an award-winning college football columnist and member of the Athlon Contributor Network. You can follow him from coast-to-coast on Twitter, Instagram and Snapchat at @BryanDFischer.