Week 5 of the 2022 NFL season kicks off with a matchup of Pro Bowl quarterbacks in new places when Indianapolis (Matt Ryan) and Denver (Russell Wilson) meet up for "Thursday Night Football." The International Series continues with the Giants and Packers playing in London while five divisional matchups also dot the slate, including both of the prime-time pairings. On "Sunday Night Football" it's Cincinnati at Baltimore and Las Vegas and Kansas City will finish things up on "Monday Night Football."
We're here to keep you updated on the full NFL regular-season schedule, including start times and byes. Athlon Sports also has the full Thursday night, Sunday night, and Monday night slates if you are looking for a more specific breakdown.
Note: All times are ET and subject to change. Flex scheduling rules apply starting Week 5 and are in effect Weeks 5-17.
Thursday, Oct. 6
Indianapolis at Denver, 8:15 p.m.
Sunday, Oct. 9
New York Giants vs. Green Bay (London), 9:30 a.m.
Pittsburgh at Buffalo, 1 p.m.
Los Angeles Chargers at Cleveland, 1 p.m.
Houston at Jacksonville, 1 p.m.
Chicago at Minnesota, 1 p.m.
Detroit at New England, 1 p.m.
Seattle at New Orleans, 1 p.m.
Miami at New York Jets, 1 p.m.
Atlanta at Tampa Bay, 1 p.m.
Tennessee at Washington, 1 p.m.
San Francisco at Carolina, 4:05 p.m.
Philadelphia at Arizona, 4:25 p.m.
Dallas at Los Angeles Rams, 4:25 p.m.
Cincinnati at Baltimore, 8:20 p.m. (SNF)
Monday, Oct. 10
Las Vegas at Kansas City, 8:15 p.m.