Patrick Mahomes has done just about everything during his four-plus seasons as the starting quarterback of the Kansas City Chiefs.
But the former Super Bowl champion and NFL MVP will face a new challenge Sunday.
For the first time in his career, Mahomes will almost certainly take the field in Kansas City as an underdog. The Buffalo Bills are currently favored by 2.5 points over the Chiefs for the marquee Week Six matchup, according to DraftKings.
Assuming that line holds, it will mark the first time in 42 home starts for Mahomes that the Chiefs will not be favored to win.
"For the first time in his career, Chiefs’ QB Patrick Mahomes is a home underdog. Mahomes had been favored in his first 41 home starts, including the playoffs, the longest streak to begin a career in the Super Bowl era." -- Adam Schefter
The line speaks to the dominance of the Bills during their 4-1 start to the season. However, it's not necessarily cause for concern for Chiefs fans.
Mahomes hasn't been an underdog many times in his NFL career, but his record when not favored is ridiculous.
In seven Mahomes starts as an underdog, the Chiefs are undefeated against the spread with a record of 6-0-1. They are 5-2 straight up.
The matchup between the Chiefs and the Bills scarcely needed more storylines. It will serve as a rematch of the overtime thriller won by the Chiefs in last year's divisional playoff round and the first meeting of 2022 for the two AFC teams with the best odds to reach the Super Bowl. Kickoff is set for 4:25 EST on CBS.