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Tampa Bay Buccaneers vs. New Orleans Saints Prediction: NFC South Rivals Set to Face Off in the Big Easy

Tom Brady looking for first regular-season win as the Bucs' QB vs. the Saints.

For all of Tom Brady's success with the Buccaneers, one team has bedeviled him: the Saints. Tampa Bay has lost all four regular-season meetings with New Orleans with Brady at quarterback. He'll get his first crack at reversing this trend when these NFC South rivals meet on Sunday in the Caesars Superdome.

Related: NFL Predictions for Every Game in Week 2

If there's any concern about the Bucs starting slow after Brady missed 11 days of the preseason, that was put to rest in the opener at Jerry World. Brady and his hand-selected band of skill players played efficiently though not spectacularly. The Bucs' defense delivered the victory by limiting the Cowboys' scoring to one field goal.