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Thursday Night Football: San Francisco 49ers vs. Arizona Cardinals Prediction and Preview

Thursday Night Football: San Francisco 49ers vs. Arizona Cardinals Prediction and Preview

Thursday Night Football: 49ers vs. Cardinals Prediction and Preview

Two of the top rookies in the NFL lead their teams into a key NFC West showdown, as Nick Bosa and the San Francisco 49ers take on Kyler Murray and the Arizona Cardinals at State Farm Stadium in Glendale. This will also provide fans with an interesting battle between creative offensive head coaches Kyle Shanahan and Kliff Kingsbury in front of a national television audience.

San Francisco demolished the Panthers on Sunday, 51-13, and the game wasn’t even that close. The 49ers improved to 7-0 for the second time in franchise history, the first time since 1990. The ground attack was lights-out for San Francisco with 232 yards on 38 attempts. Tevin Coleman rushed for 105 yards on 11 carries and three touchdowns and also picked up a fourth score with a 10-yard reception in the second quarter. Nick Bosa was just about unstoppable with four tackles, including three for loss, three sacks, and an interception. Richard Sherman and Emmanuel Moseley also intercepted Kyle Allen, as the Panthers quarterback could not get anything going in the passing game for Carolina.

Meanwhile, Arizona (3-4-1) was solid down in New Orleans last week, where they were within striking distance of an upset of the Saints in the second half. However, New Orleans put the hammer down late and pulled away from the Cardinals, 31-9 at the Mercedes Benz Superdome. Kyler Murray was 19 of 33 for 220 passing yards but wasn’t able to stretch the Saints' defense. The Cardinals only had one huge explosive play all day — a 47-yard pass to Charles Clay. Running the football remains a problem for Arizona; they were only able to generate 40 yards on 11 attempts and Chase Edmonds joined the ever-growing injured ranks. Drew Brees made his return for the Saints and shredded the Cardinals secondary for 373 yards and three touchdown passes.