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Top 5 Games for NFL's Week 2 Schedule

Week 2 to start and end with marquee matchups, including a MNF doubleheader.
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The opening week of the NFL season is finally over, which means it's time to look ahead to Week 2. And while there aren't as many high-profile matchups as there were to start the season, there's still plenty to look forward to.

Noticeably missing in this week's slate of top games is Bengals-Cowboys. That would have easily landed at No. 2, but with Dallas QB Dak Prescott out several weeks with a broken thumb, Cooper Rush and Co. probably won't be much of a challenge for the reigning AFC champs.

What remains is three prime-time games, a rivalry matchup, and two bubble playoff teams hoping to get back in the win column.

(Note: All games listed in ET)

Top 5 Games of Week 2

5. Titans vs. Bills, Monday at 7:15 p.m.

The Bills were maybe even better than advertised — and they were Athlon's Super Bowl pick — while the Titans found a way to blow a game at home to the Giants. However, these teams have played each of the last four seasons, and it's been close almost every time. Aside from a 42-16 Titans blowout in 2020, the other three were decided by a combined 11 points. Could this be a potential playoff preview?

4. Cardinals vs. Raiders, Sunday at 4:25 p.m.

After tough season-opening losses, these West Division teams have a chance to get back on schedule with a signature win. And since neither defense is very good, you can expect plenty of offense. One key to watch is that Raiders pass rusher Chandler Jones will be going up against his former team, which doesn't exactly have a strong offensive line.

3. Vikings vs. Eagles, Monday at 8:30 p.m.

These teams looked like top wild-card contenders, but after Week 1 victories, they're dreaming even bigger. Kevin O'Connell could hardly have imagined a better game for his head-coaching debut, and Jalen Hurts looked the part of a franchise quarterback. Are these teams real threats in the NFC playoff picture?

2. Buccaneers vs. Saints, Sunday at 1 p.m.

For all the success that Tom Brady has had since joining the Bucs, the one thing he's really struggled with is playing the Saints. Brady has yet to beat the Saints in the regular season and has been outscored 117-53 in those four games, although he did win the lone playoff game. Will the Saints continue to have his number under new leadership?

1. Chargers vs. Chiefs, Thursday at 8:20 p.m.

All Chargers-Chiefs games are appointment television, and it's great that the first one comes in prime time. Justin Herbert and rightfully been getting lots of preseason MVP buzz, but Patrick Mahomes proved in Week 1 that he's still the top dog until proven otherwise. The Chiefs look as dangerous as ever, even without Tyreek Hill, because they have the best QB in the league.