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Here are this week’s picks from Athlon Sports senior editor John Gworek:
Thursday’s Game
Atlanta at New Orleans
The Falcons are unbeaten but have been dodging bullets all season. This is the week their porous pass defense finally bites them.
Gworek's Pick: New Orleans, 30–28.
Sunday’s Games
Washington at N.Y. Jets
Coming off an overtime loss, Kirk Cousins and the Redskins face a rested Jets team that has forced the most turnovers in the NFL.
Gworek's Pick: N.Y. Jets, 20–13.
Arizona at Pittsburgh
The Steelers escaped on Monday night, but if the Cards can protect Carson Palmer, he will find holes in the Pittsburgh secondary.
Gworek's Pick: Arizona, 26–20.
Kansas City at Minnesota
The Vikings are rested and unbeaten at home, while Kansas City limps into town without top weapon Jamaal Charles.
Gworek's Pick: Minnesota, 23–17.
Cincinnati at Buffalo
Tyrod Taylor was hurting after leading a comeback win at Tennessee. If he can’t go, Buffalo’s odds of pulling the upset drop considerably.
Gworek's Pick: Buffalo, 21–20.
Chicago at Detroit
Detroit is winless, and Matthew Stafford keeps thowing the ball to the other team. But is this a Chicago team that can win three in a row?
Gworek's Pick: Detroit, 28–20.
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Denver at Cleveland
Josh McCown has been putting up huge numbers for Cleveland, but Denver’s defense is a different animal.
Gworek's Pick: Denver, 27–14.
Houston at Jacksonville
The Texans just keep finding a way to lose games and somehow are 25th in scoring despite ranking fifth in total yards.
Gworek's Pick: Jacksonville, 23–20.
Miami at Tennessee
The Titans have blown back-to-back fourth-quarter leads at home, but rookie quarterback Marcus Mariota hasn’t looked overmatched.
Gworek's Pick: Tennessee, 20–16.
Carolina at Seattle
The Seahawks was cruising to a third straight win before blowing a big lead at Cincinnati. Carolina is 4–0 but has beaten teams that are a combined 5–15.
Gworek's Pick: Seattle, 17–13.
San Diego at Green Bay
After a last-second loss on Monday night, the Chargers have to head to Lambeau Field. Green Bay looking to hit its bye undefeated.
Gworek's Pick: Green Bay, 30–20.
Baltimore at San Francisco
The 1–4 Ravens play their next two out West with a trip to Arizona looming. The 49ers have lost four in a row since winning in Week 1.
Gworek's Pick: Baltimore, 27–26.
New England at Indianapolis
Indianapolis is 3–0 against its own division and 0–2 against New England’s. And the Patriots are the class of that division.
Gworek's Pick: New England, 30–17.
Monday’s Game
N.Y. Giants at Philadelphia
Both of these offenses put up more than 500 yards last week. They Eagles are 26th in pass defense, the Giants are 32nd. Look for a shootout.
Gworek's Pick: N.Y. Giants, 34–33.
Week 5 Record: 8–6
Overall Record: 49–28